The Australian tennis star's aspirations of advancing to the ATP Finals semi-finals are hanging by a thread after a heartbreaking three-set loss to Italian opponent Lorenzo Musetti.
The seventh-ranked player succumbed 7-5 3-6 7-5 after being unable to close out the match, keeping the Italian to remain in the tournament and now forcing the Australian needing to decisively defeat Taylor Fritz in his last group match to reach the semi-finals.
But facing Fritz in 48 hours is the smallest of de Minaur's immediate concerns as the Sydney native admits he must address the mental demons that risk undermining his career.
A loser of all six of his grand slam quarter-final appearances, the 26-year-old was unable to disguise his anguish after suffering yet another high-stakes near miss with his finals destiny in his own hands.
"I don't know how many times I can deal with a loss like this one," de Minaur stated in Turin. "I must talk to my team and try to sort out these issues because these are challenges that can't keep happening."
"Essentially, if I really want to be serious about taking the next step in my career, these contests, I can't lose them. I just must not. It seems as if I've lost a lot of them this year. More than anything, it's getting to a point where mentally it's destroying me."
Characterizing his feelings as "very bleak", de Minaur lamented a succession of final set collapses in 2025 and said he must find a way to win the tight encounters.
The top-ranked Australian's streak of devastating defeats comprise:
"I continue investing everything into these matches," de Minaur commented. "Whenever the outcome isn't positive, it's hard to keep pushing through."
"This is an issue that if it isn't resolved, it's going to eat me alive. I must get it sorted sooner rather than later."
De Minaur and Fritz are tied at five wins each in past meetings, though the American world No 6 won their matchup in this showpiece event last year.
The Australian's hopes remain flickering after Fritz experienced a 6-7 (2-7) 7-5 6-3 defeat to Carlos Alcaraz that guaranteed the Spaniard would advance to the semi-finals as the winner of the Jimmy Connors group.
The second-ranked player's victory, having already defeated de Minaur, put Alcaraz within one win of securing the year-end top ranking from Jannik Sinner.
Regardless if he loses to Musetti in his last round-robin contest, Alcaraz will regain the world No 1 ranking except if Sinner, who defeated Auger-Aliassime in his first match on Monday, goes undefeated to defend his ATP Finals title.
"I'll attempt not to focus on it," said Alcaraz. "It's going to be a extremely important match for me. I will try not to let the nerves play a bad time in the match. I will concentrate on my goals, about feeling much better than today."
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